At 14:00 on June 21, 2023, Professor Guo Xuefeng of Peking University gave a lecture on "opportunities and challenges of single molecule Science" at the University of the Chinese Academy of Sciences at the invitation of Professor Huang Hui.

Professor Guo Xuefeng first demonstrated his continued interest and great efforts in developing efficient lithography methods that can be used to create molecular electronic devices through the combination of top-down micro / nano processing and bottom-up molecular assembly. These devices use nano-coated carbon materials such as single-walled carbon nanotubes (SWCNTs) and graphene as point contacts and are formed by electron beam lithography and precision oxygen plasma etching. Through a strong amide bond, the functional molecules bridged with the diamine group are covalently connected to the carboxylic acid functionalized nano-Gap to form a stable carbon electrode-molecular connection with the desired function. Then, using these methods, we reveal the dependence of the charge transport of a single metal-DNA double strand on the stacking integrity, and fabricate molecular devices that can realize unlabeled, real-time electrical detection of chemical reactions or biological interactions at the level of a single event, or switch their molecular conductance when exposed to external stimuli such as electric field, magnetic field, ion, pH and light. Finally, Professor Guo Xuefeng communicated and discussed with the teachers and students at the scene, and received a warm response from the teachers and students at the scene.

Guo Xuefeng is a special professor at Peking University, winner of the National Outstanding Youth Fund and a leader in scientific and technological innovation in the Ten Thousand talents Plan of the Organization Department of the CPC Central Committee. He received his bachelor's and master's degrees from Beijing normal University in 2001, received his doctorate from the Institute of Chemistry of the Chinese Academy of Sciences in 2004, engaged in postdoctoral research at Columbia University from 2004 to 2007, and joined Peking University in 2008. Having been engaged in the research of molecular materials and devices for a long time, we have developed a breakthrough method for the preparation of stable single molecule devices, constructed the first stable and controllable single molecule electronic switching device in the world, and developed the core technology of single molecule electrical detection. it has opened up a new field of single molecule science and technology research.