At 14:00 on June 23, 2023, Professor Liu Dongsheng of Tsinghua University was invited by Professor Huang Hui to give a lecture on the theme of "Nucleic Acid Supramolecular Hydrogel" at the "Advanced Materials and Technology" Forum of the University of Chinese Academy of Sciences. Building 114 classroom held.

In his report, Professor Liu proposed a supramolecular hydrogel model with a fully rigid molecular structure, which can avoid the topological pores caused by the entropy curling of high molecular chains, and make it have ultra-high permeability similar to extracellular matrix.

Taking advantage of the high rigidity and water solubility of nucleic acid double-stranded molecules, a series of nucleic acid supramolecular hydrogels were constructed through sequence and structure design, and the high permeability of the fully rigid molecular network was proved by experiments and theoretical simulations. This kind of hydrogel also has the characteristics of high strength, fast gelation, injectability, self-healing and good biocompatibility. On this basis, its biomedical application has been explored, and research has proved that the gel can carry stem cells , Utilizing autologous signals secreted by the injured part of the organism to regulate the proliferation and differentiation of stem cells has achieved excellent results in the repair of total spinal cord injury. Using the designability of nucleic acid sequences, they also achieved univariate regulation of the mechanical properties of the hydrogel material based on the structure of the gel, and studied the influence of the mechanical properties of the material on the differentiation of stem cells. The results proved that the mechanical properties will not affect the sleeve Have a direct impact on the differentiation of stem cells. Finally, Professor Liu Dongsheng communicated and discussed with the teachers and students on site, and received enthusiastic responses from the teachers and students on site.

Introduction to the speaker: Liu Dongsheng, Distinguished Professor of Cheung Kong Scholars of the Ministry of Education, Department of Chemistry, Tsinghua University, doctoral supervisor. Fellow of the Chinese Chemical Society, Fellow of the Royal Society of Chemistry; Selected into the Young and Middle-aged Scientific and Technological Innovation Leading Talents Program of the Innovative Talents Promotion Program, the leading talent of the "Ten Thousand Talents Program" of the Organization Department of the Central Committee of the Communist Party of China, and won the "First Chinese Chemical Society~Royal Chemistry of the United Kingdom" Youth Chemistry Award of Chinese Chemical Society", "The 7th BASF Youth Knowledge Innovation Award of Chinese Chemical Society". Served as the person in charge of the "Outstanding Youth Fund", key projects, and innovative group projects of the Fund Committee, and the chief scientist of the major basic research project (973 project) of the Ministry of Science and Technology. He is currently the deputy editor-in-chief of "Polymer", "Acta Polymer Sinica", "Journal of Higher School Chemistry", and the secretary-general of the Polymer Discipline Committee of the Chinese Chemical Society. Mainly engaged in the research of nucleic acid synthesis and modification, nucleic acid supramolecular materials.